Lwanyi Mayonbo Lagos
Scott hospital, Lesotho
Title: The effect of anti-retroviral therapy (only one drug Zidovudine as a prophylaxis or 3 Antiretroviral drugs) on the new born birth weight at Scott hospital in Lesotho from 2008 to 2015
Biography
Biography: Lwanyi Mayonbo Lagos
Abstract
Lesotho is one of the countries in the world with a high burden of HIV, with a prevalence of 23% and this condition still a challenge for the entire population and the government of the kingdom of Lesotho. Many kinds of neglected disease are developing also in this area. A study on a specific group of population which is the pregnant women and their babies’ birth weight was conducted in Scott hospital with is one of the district hospitals In Lesotho. Before conducting the study many literatures on different sources including PubMed were reviewed The cases were babies born from HIV positive mothers on only one drug( zidovudine) during pregnancy time as a prophylaxis (option A) and the control which was the group of babies born from HIV positive mothers on full antiretroviral therapy(3 drugs) during the pregnancy time( B and B+) . After analysis of data, we find that the mean weight in option A was 3010, 416 with a stand error of 302106 at 95% CI: 2950,923 – 3069,909. The mean weight in option B or B+ was 298,578 with the standard error of 41, 61805 at 95% CI: 2899,224 ¬- 3063,224. the combined mean weight was 2, 8838 with a standard error of 3, 72099 at 95%. CI: 21, 51773 – 36, 15827.the calculated T value was 7, 7457 with 383 degrees of freedom. Therefore we realize that the mean weight in option A was superior compared to the mean weight in option B/ B+. 310,416 > 298,578. It means when Zidovudine is used in pregnancy as the prophylaxis it doesn’t have a negative effect on the weight (low birth weight) but when several anti-retroviral therapy drugs are combined during pregnancy there may have an effect on the baby’s weight. (Low birth weight.) Presently the prevention mother to child transmission of HIV, (PMTCT) in Lesotho still on-going successfully with a positive result (reduce in a number of babies congenital HIV) and must be strengthened because of it a strong strategy in the fight of this pandemic viral infectious disease (HIV). I would like in the near future to conduct more research on the specific antiretroviral therapy regimen and their effect on pregnancy and extend the research to same neglected tropical diseases associated with HIV.